Chemistry data
- Class
- endogenous neuropeptide / anorexigenic signaling peptide
- Molecular weight
- 12829 g/mol
- Sequence
- Active fragment CART (55-102): 48 amino acids; full prepro-CART: 116 amino acids
- Half-life
- not well characterized in vivo
- Routes
- intracerebroventricular (research only) · intraperitoneal (animal research)
- Studied doses
- intracerebroventricular 0.1–2.0 µg per injection in rodent models
Status Regulacyjny
- Stany Zjednoczone
- research_only
- Unia Europejska
- research_only
- Wielka Brytania
- research_only
Jak to działa
- Anorexigenic signaling via Gi/o protein-coupled receptors in hypothalamic nuclei
- Positive regulation by leptin in the arcuate nucleus, linking CART to adiposity signaling
- Modulation of dopaminergic reward pathways in the nucleus accumbens
- Synergistic appetite suppression with cholecystokinin (CCK) in vagal afferent signaling
Wyniki badań
- appetite-suppression preclinical
- energy-homeostasis preclinical
- body-weight-regulation preclinical
- reward-pathway-modulation preclinical
Kontekst dawkowania
-
- Drogi Podania
- intracerebroventricular
- Zakres
- 0.1–2.0 µg per injection in rodent models
animal research only; no human dosing data exists
🧮 Reconstitution Calculator
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Efekty uboczne: kontekst badań
- no human safety data available
- CART knockout mice show increased body weight and fat mass on high-fat diets (preclinical)
- site-specific paradoxical orexigenic effects observed with direct intranuclear injection in rodents
Pełne podsumowanie badań wkrótce. Tymczasem zajrzyj do danych naukowych i referencji PubMed powyżej.
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