Chemistry data
- Class
- endogenous neuropeptide / anorexigenic signaling peptide
- Molecular weight
- 12829 g/mol
- Sequence
- Active fragment CART (55-102): 48 amino acids; full prepro-CART: 116 amino acids
- Half-life
- not well characterized in vivo
- Routes
- intracerebroventricular (research only) · intraperitoneal (animal research)
- Studied doses
- intracerebroventricular 0.1–2.0 µg per injection in rodent models
Stato Normativo
- Stati Uniti
- research_only
- Unione Europea
- research_only
- Regno Unito
- research_only
Come funziona
- Anorexigenic signaling via Gi/o protein-coupled receptors in hypothalamic nuclei
- Positive regulation by leptin in the arcuate nucleus, linking CART to adiposity signaling
- Modulation of dopaminergic reward pathways in the nucleus accumbens
- Synergistic appetite suppression with cholecystokinin (CCK) in vagal afferent signaling
Risultati della ricerca
- appetite-suppression preclinical
- energy-homeostasis preclinical
- body-weight-regulation preclinical
- reward-pathway-modulation preclinical
Contesto di dosaggio
-
- Vie di Somministrazione
- intracerebroventricular
- Intervallo
- 0.1–2.0 µg per injection in rodent models
animal research only; no human dosing data exists
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Effetti collaterali: contesto di ricerca
- no human safety data available
- CART knockout mice show increased body weight and fat mass on high-fat diets (preclinical)
- site-specific paradoxical orexigenic effects observed with direct intranuclear injection in rodents
Il riassunto completo della ricerca arriverà presto. Nel frattempo, consulta i dati scientifici e i riferimenti PubMed sopra.
Pagine Correlate
- appetite suppression
- weight loss
- neuropeptides
- cart vs leptin
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Mitochondrial-encoded peptide studied for metabolic regulation and longevity
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Selective growth hormone secretagogue