Chemistry data
- Class
- GLP-1 receptor agonist (incretin mimetic)
- Molecular weight
- 4113.6 g/mol
- Sequence
- modified 31-amino-acid peptide with Aib8, Arg34, and C18 fatty diacid chain
- Half-life
- approximately 1 week (168 hours)
- Routes
- subcutaneous · oral
- Studied doses
- subcutaneous 0.25 mg to 2.4 mg once weekly (titrated over 16-20 weeks) · subcutaneous 0.5 mg to 2 mg once weekly · oral 3 mg to 14 mg once daily
Stato Normativo
- Stati Uniti
- fda_approved
- Unione Europea
- ema_approved
- Regno Unito
- mhra_approved
Come funziona
- GLP-1 receptor activation and glucose-dependent insulin secretion
- Central appetite suppression via hypothalamic POMC/CART and NPY/AgRP neurons
- Delayed gastric emptying and increased satiety signaling
- AMPK/SIRT1 pathway activation and adipose tissue browning
- NF-κB inhibition and anti-inflammatory macrophage modulation
- SIRT1/NRF2 antioxidant pathway activation
Risultati della ricerca
- weight-loss phase_3_clinical
- glycemic-control phase_3_clinical
- cardiovascular-risk-reduction phase_3_clinical
- appetite-regulation phase_3_clinical
- metabolic-optimization phase_3_clinical
Contesto di dosaggio
-
- Vie di Somministrazione
- subcutaneous
- Intervallo
- 0.25 mg to 2.4 mg once weekly (titrated over 16-20 weeks)
STEP clinical trials for chronic weight management (Wegovy)
-
- Vie di Somministrazione
- subcutaneous
- Intervallo
- 0.5 mg to 2 mg once weekly
SUSTAIN trials for type 2 diabetes (Ozempic)
-
- Vie di Somministrazione
- oral
- Intervallo
- 3 mg to 14 mg once daily
PIONEER trials for type 2 diabetes (Rybelsus); must be taken on empty stomach with ≤120 mL water ≥30 min before food
🧮 Reconstitution Calculator
Determine exactly how much bacteriostatic water to add and how many units to draw for your target dose.
Effetti collaterali: contesto di ricerca
- nausea (most common, ~44% during titration, typically diminishes)
- vomiting (~24%)
- diarrhea (~30%)
- abdominal pain (~10%)
- constipation (~24%)
- decreased appetite
- injection site reactions
- headache
- fatigue
Il riassunto completo della ricerca arriverà presto. Nel frattempo, consulta i dati scientifici e i riferimenti PubMed sopra.
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Comparison